Narcolepsy Risk DNA Test

$195.00

Do you find yourself struggling to stay awake during the day, despite a full night’s sleep? The Genovate Narcolepsy Risk DNA Test may provide the answers you need. This test is designed to detect the presence of the HLA-DQB1*06:02 allele, which is strongly associated with narcolepsy, a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep.

Detects the HLA-DQB1*06:02 variant associated with narcolepsy
Carriers of two copies of the allele have a 7X to 25X increased risk of developing narcolepsy.
Receive 100% private and confidential online results
Simple and painless mouth swab sample collection

Description

What is Narcolepsy?

Narcolepsy is a sleep disorder that affects the brain’s ability to regulate sleep-wake cycles. Symptoms include excessive daytime sleepiness, sleep paralysis, hallucinations, and in some cases, cataplexy—sudden, brief loss of muscle tone. It is a condition that can significantly impact daily activities, making it difficult for sufferers to live a normal life.

How common is Narcolepsy?

Narcolepsy affects approximately 1 in 2000 to 1 in 5000 individuals, yet only about 25% receive an accurate diagnosis. Misdiagnoses are common, often attributing symptoms to psychiatric or emotional issues. Family members of affected individuals have a substantially increased risk, up to 20-40 times higher than the general population.

The Genovate Narcolepsy Risk DNA Test is a valuable tool for individuals experiencing symptoms of narcolepsy or those with a family history of the disorder.

The Genetics

The Genovate Narcolepsy Risk DNA Test identifies the presence of the HLA-DQB1*06:02 allele associated with narcolepsy, which is present in approximately 90-99% of individuals with narcolepsy. This allele is part of the human leukocyte antigen (HLA) system, which is crucial for the immune system’s ability to distinguish between self and non-self molecules.

Having two copies of HLA-DQ1b*06:02 puts you at 7 to 25 times higher risk
Having one copy of HLA-DQB1*06:02 along with another gene variant increases risk by 3 times
If you don’t have HLA-DQB1*06:02, your risk of narcolepsy is lower

While the HLA-DQB1*06:02 allele is a significant genetic factor, it is important to note that not all individuals with this allele develop narcolepsy, indicating that other genetic and environmental factors also play a role in the condition.

Symptoms of Narcolepsy

Excessive daytime sleepiness, making it difficult to concentrate and stay awake.
Cataplexy, resulting in temporary loss of muscle control, often triggered by emotions such as laughter and anger.
Sleep paralysis, causing a temporary inability to move or speak when waking up or falling asleep.
Microsleeps, or brief episodes of sleep that can occur at any time.
Memory problems, headaches, and restless sleep, including vivid nightmares and physically acting out dreams
Hallucinations, particularly when going to sleep or waking up.
Waking up frequently throughout the night or having trouble staying asleep.

How it works

Order your kit

The kit will be delivered discreetly to you. There is no need to leave the comfort of your home.

Collect your sample

Activate your kit online, then collect your sample and return it to our lab using the prepaid envelope included in the kit.

Receive your results

View or download your results from your online account. We will send you an email immediately after your test is finished.