Celiac Disease DNA Test

$249.00

Are you at increased risk of celiac disease? Almost all people who have celiac disease carry carries at least one genetic risk allele. Find out your risk with this DNA test.

Includes HLA variants associated with increased risk
Negative results rules out celiac disease for life
Accurate even on a gluten-free diet
No age limit
24/7 online status check

Description

What is celiac disease?

Celiac disease is an autoimmune disorder, where the immune system attacks and destroys healthy cells by mistake. People with celiac disease (CD) are extremely sensitive to gluten, a protein found in wheat, rye, barley and oats.

When an individual with CD consumes gluten, their immune system reacts aberrantly, causing severe damage to the lining of the small intestine, and a variety of health complications.

The consumption of gluten is not needed for an accurate result from this genetic analysis. A simple mouth swab DNA sample is all that is required.

The Genetics

Almost all people with celiac disease have at least one genetic risk allele in their HLA genes. This DNA test detects nucleotide changes that occur in the three CD-associated alleles of the HLA-DQA1 and HLA-DQB1 genes (HLA-DQA1*05, HLA-DQB1*02, HLA-DQB1*0302).

These CD-associated variants can also pair together to form proteins known as DQ2 and DQ8. The presence or absence of these variants gives an indication of the risk of gluten sensitivity and CD. The risk of CD is extremely low if none of these CD-associated alleles are present.

Genetic Variants Identified in This Test

Patient Genotype (celiac-associated alleles present) vs Celiac Disease Risk

DQ2 and DQ8: 1:7
DQ2 and Homozygous HLA-DQB1*02: 1:10
DQ2 and DQ2: 1:10
DQ8 and DQ8: 1:12
DQ8 and HLA-DQB1*02: 1:24
Homozygous HLA-DQB1*02: 1:26
DQ2: 1:35
DQ8: 1:89
Heterozygous HLA-DQB1*02: 1:210
HLA-DQA1*05: 1:1842
No HLA celiac-associated alleles detected: Not at risk of developing celiac disease, less than 1:2518

Digestive symptoms of Celiac Disease

Flatulence
Bloating
Constipation and/or diarrhea
Appetite changes
Pale or bloody stools
Nausea and vomiting

How it works

Order your kit

The kit will be delivered discreetly to you. There is no need to leave the comfort of your home.

Collect your sample

Activate your kit online, then collect your sample and return it to our lab using the prepaid envelope included in the kit.

Receive your results

View or download your results from your online account. We will send you an email immediately after your test is finished.